Apex Cortisol+ — KSM-66 Adaptogen Stack
Bring cortisol back under control and get your calm, focused edge back.
600 mg of KSM-66 ashwagandha reduced serum cortisol by 27.9% from baseline in a 60-day randomized, double-blind, placebo-controlled trial (Chandrasekhar et al., 2012) — the exact standardized extract and dose in every Apex Cortisol+ serving.
- 600 mg KSM-66, the exact standardized extract and dose used in the 2012 randomized controlled trial
- 5 clinically-dosed ingredients on the label, not a hidden proprietary blend
- Third-party lab tested for identity, potency, heavy metals
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The clinical-strength adaptogen stack for executives running hot.
KSM-66® Ashwagandha at the dose validated by 40+ RCTs (600 mg, 5% withanolides), reinforced by four traditional adaptogens — Shatavari, Panax Ginseng, Maca, L-Arginine — and the foundational micronutrients your nervous system needs to recover under load.
Built for the operator who already takes care of sleep and training, and needs the next layer: cortisol regulation without sedation, drive intact, mornings reset.
- KSM-66® Ashwagandha Extract — 600 mg, standardized to 5% withanolides. The most-studied form (40+ RCTs on stress reactivity, cortisol, sleep architecture, libido).
- Shatavari Root — 50 mg. Traditional adaptogen used alongside ashwagandha in Ayurveda for nervous-system reset.
- Panax Ginseng Root — 100 mg. Adaptogen with millennia of use for sustained energy without crash.
- Maca Root — 150 mg. Andean adaptogen supporting stamina and balance.
- L-Arginine — 300 mg. Amino acid supporting healthy circulation.
- Vitamin D3 — 20 mcg / 100% DV. Vitamin B6 — 2.5 mg / 147% DV. Vitamin B12 (methylcobalamin) — 25 mcg / 1042% DV.
Ashwagandha Apex ($29.90) is a clean single-ingredient organic root extract — perfect if you want to start simple.
Apex Cortisol+ is the next tier: KSM-66 standardized extract (the form with the published trial data) plus four supporting adaptogens calibrated for the executive who's already optimized the basics.
Two capsules daily, with a meal. Most users report a noticeable shift in stress reactivity within 7-14 days, with peak benefits at 4-6 weeks (the same window most KSM-66 RCTs report).
Adapt under load.
60 capsules / 30 days. Manufactured in the USA in an FDA-registered facility for Apexzen. Free from gluten, GMOs, lactose, alcohol, corn, hormones, antibiotics. Vegetarian (HPMC capsule), Halal-certified.
Suggested use: As a dietary supplement, adults take two (2) capsules daily. For best results, take with 6-8 oz (177-237 ml) of water or as directed by a healthcare professional.
Warning: Do not exceed recommended dose. Pregnant or nursing mothers, children under the age of 18, and individuals with known medical conditions should consult a physician before using this or any dietary supplement. Keep out of the reach of children. Do not use if safety seal is damaged or missing. Store in a cool, dry place.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. KSM-66® is a registered trademark of Ixoreal Biomed.
KSM-66 ashwagandha and cortisol: the actual numbers.
In a randomized, double-blind, placebo-controlled trial of 64 adults with chronic stress, 600 mg per day of KSM-66 ashwagandha root extract taken for 60 days reduced serum cortisol by 27.9% from baseline, compared with a 7.9% reduction in the placebo group (Chandrasekhar et al., 2012, Indian Journal of Psychological Medicine). These are within-group changes from baseline, not a promise about any individual result. Apex Cortisol+ delivers 600 mg of KSM-66 per 2-capsule serving, standardized to 5% withanolides — the same standardized extract and dose used in the trial, not a generic root-powder substitute.
The other four ingredients are dosed alongside KSM-66 but are not the subject of that cortisol trial. Shatavari (50 mg) and Panax Ginseng (100 mg) are traditional Ayurvedic and East Asian adaptogens with long historical use for nervous-system resilience and sustained energy. Maca (150 mg) is an Andean root traditionally used for stamina and hormonal balance. L-Arginine (300 mg) is an amino acid that supports healthy circulation. Vitamins D3, B6 and B12 are included at standard supportive doses for nervous-system function. None of these four carries the same cortisol-specific clinical data as KSM-66; they are included as a traditional-use adaptogen layer, not as additional clinically-dosed cortisol claims.
Ashwagandha is an adaptogen, not a fast-acting sedative: effects build over roughly 4 to 8 weeks, which is why Apexzen documents an 8-weeks-on, 1-to-2-weeks-off cycling protocol.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Questions on Apex Cortisol+ and KSM-66
How much does KSM-66 lower cortisol?
In the Chandrasekhar et al. 2012 trial, 600 mg per day of KSM-66 ashwagandha root extract reduced serum cortisol by 27.9% from baseline over 60 days in adults with chronic stress, versus 7.9% with placebo. Apex Cortisol+ uses the same standardized KSM-66 extract at the same 600 mg dose. That is a within-group reduction measured in a trial population, not a claim about what any individual will see. These statements have not been evaluated by the FDA.
What do the other four ingredients do?
Shatavari, Panax Ginseng and Maca are traditional adaptogens used in Ayurvedic and East Asian practice for nervous-system resilience, sustained energy and stamina; L-Arginine supports healthy circulation. They are included at label-stated doses alongside KSM-66, but the 27.9% cortisol figure above is specific to KSM-66 and was not measured for this four-ingredient layer.
How is this different from Ashwagandha Apex?
Ashwagandha Apex is a single-ingredient organic ashwagandha root product with no standardized extract. Apex Cortisol+ uses KSM-66, the standardized, clinically-studied extract, at the trial-matched 600 mg dose, plus four supporting adaptogens. Start with Ashwagandha Apex for a clean single ingredient; move to Apex Cortisol+ for the standardized clinical extract and a fuller stack.
Will this interact with my medication?
Ashwagandha can interact with thyroid medication, sedatives, immunosuppressants, and blood pressure medication; Panax Ginseng can interact with blood thinners and diabetes medication. If you take prescription medication, are pregnant or nursing, or have an autoimmune, thyroid, or blood pressure condition, talk to your physician before starting.
What if Apex Cortisol+ doesn't work for me?
30-day money-back guarantee, no restocking fee, no questions. Email founders-circle@apexzenlabs.com from the address you ordered with.